| Integrin, alpha X (complement component 3 receptor 4 subunit) | |||||||||||||
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PDB rendering based on 1n3y. |
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| Identifiers | |||||||||||||
| Symbols | ITGAX; CD11C; SLEB6 | ||||||||||||
| External IDs | OMIM: 151510 MGI: 96609 HomoloGene: 55493 GeneCards: ITGAX Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3687 | 16411 | |||||||||||
| Ensembl | ENSG00000140678 | ENSMUSG00000030789 | |||||||||||
| UniProt | P20702 | Q3TD13 | |||||||||||
| RefSeq (mRNA) | NM_000887.3 | NM_021334.2 | |||||||||||
| RefSeq (protein) | NP_000878.2 | NP_067309.1 | |||||||||||
| Location (UCSC) | Chr 16: 31.37 – 31.39 Mb |
Chr 7: 135.27 – 135.29 Mb |
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| PubMed search | [1] | [2] | |||||||||||
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a human gene.[1]
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[1]
CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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